Pancreatic Cancer

Pancreatic Cancer: Pancreatic ductal adenocarcinoma is the most common type of pancreatic cancer and is characterized by highly dense stroma. The stroma is comprised of tumor associated macrophages, cancer associated fibroblasts, regulatory T cells, pancreatic stellate cells, dendritic cells and neutrophils. Among these stromal cells, macrophages constitute major leukocyte infiltrate and it inhibits adaptive immune responses and limit the efficacy of chemotherapy in this cancer. We are studying the role of Syk kinase in the progression and tumorigenesis of pancreatic cancer.