Neuroblastoma

Neuroblastoma: Our lab is focused on finding novel targets for treatment of neuroblastoma. Neuroblastoma is an extremely heterogeneous pediatric tumor that arises from neural crest and progression of this tumor is associated with infiltration of macrophages that foster tumor growth and harbor immunosuppressive functions. Currently, we are studying the signaling cascades that regulate recruitment and activation of macrophages in MYCN amplified and non-MYCN amplified pediatric neuroblastoma (NB) tumors. This study will shed new light on macrophage targeted therapies in neuroblastoma.